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In a groundbreaking discovery, researchers have uncovered the first physical evidence of psychedelic substances used in ancient Egyptian rituals. A 2,200-year-old Bes mug, housed at the Tampa Museum of Art, has revealed its secrets through advanced chemical and DNA analyses, shedding light on the enigmatic spiritual practices of ancient Egypt. Decorated with the face of Bes, the god of fertility, protection, and joy, this artifact connects us to a fascinating era where religion, medicine, and mysticism intertwined.

The Bes Mug

The Bes mug, one of the few remaining from the Ptolemaic period (circa 330–30 BCE), was named after the deity it depicts. Bes was a guardian figure associated with fertility, childbirth, and household well-being. His popularity spanned centuries, evolving to encompass mystical roles in oracular rituals. The study, published in Scientific Reports and conducted by an international team led by Professor Davide Tanasi of the University of South Florida, delved into the purpose of these vessels, which had puzzled Egyptologists for decades.

“For a very long time now, Egyptologists have been speculating what mugs with the head of Bes could have been used for,” said Branko van Oppen, curator of Greek and Roman art at the Tampa Museum of Art. “Were they used for sacred water, milk, wine, or beer? Daily life or magic rituals? This discovery finally provides answers.”


The Psychedelic Cocktail

To unlock the mysteries of the Bes mug, the research team scraped minuscule samples from the inner walls of the vase. Using state-of-the-art techniques like infrared spectroscopy and ancient DNA extraction, they identified a complex mixture of ingredients, including:

    • Psychoactive Plants: Traces of Peganum harmala (Syrian rue) and Nymphaea caerulea (blue water lily) were detected. Syrian rue contains harmine and harmaline, alkaloids that induce dream-like visions, while blue water lily’s aporphine alkaloid is linked to mild sedative and euphoric effects.

    • Flavoring Agents: Ingredients like honey, sesame seeds, pine nuts, licorice, and grapes were used to enhance the flavor and give the liquid a blood-like appearance, adding symbolic significance.

    • Human Bodily Fluids: Blood, breast milk, and mucous fluids were also present, underscoring the ritualistic and symbolic aspects of the concoction.

“This research teaches us about magical rituals during the Greco-Roman period in Egypt,” Van Oppen explained. “The combination of ingredients may have been used in a dream-vision inducing ritual, possibly related to fertility or childbirth.”


Key Characteristics of Peganum harmala (Syrian rue)

  • Beta-Carboline Alkaloids: Harmine and harmaline are the primary active compounds. These alkaloids inhibit the breakdown of serotonin and other neurotransmitters in the brain by blocking the MAO enzyme. This inhibition can result in dream-like visions, heightened awareness, and altered perception.
  • Lack of DMT: Unlike ayahuasca, Peganum harmala does not contain dimethyltryptamine (DMT), the powerful hallucinogen responsible for the intense visions associated with ayahuasca brews.
  • Traditional Uses: Syrian rue has been used historically for its psychoactive effects in spiritual rituals and its medicinal properties, such as treating parasites, inflammation, and mental health conditions.

Key Characteristics of Blue Lotus (Nymphaea caerulea)

  • Active Compounds: Blue lotus contains aporphine and nuciferine, alkaloids known for their psychoactive and sedative properties. These compounds act as dopamine receptor agonists, promoting feelings of relaxation, mild euphoria, and heightened sensory perception.

  • Psychoactive Effects: Unlike Peganum harmala or ayahuasca, blue lotus does not produce strong hallucinogenic experiences. Instead, its effects are more subtle, offering a calming and mildly euphoric state that can enhance meditative or spiritual practices. Users often report enhanced dream states, making it valuable in rituals involving dream incubation or symbolic visioning.

  • Traditional Uses: In ancient Egypt, blue lotus was highly revered as a sacred plant. It was commonly associated with rebirth, healing, and spiritual connection. It featured prominently in art, religious iconography, and funerary rituals, symbolizing divine access and renewal. It was also used recreationally for its soothing effects and as an aphrodisiac.

Trip-Inducing Magic and Fertility Rituals

The presence of psychotropic substances, alcohol, and human-derived materials points to the Bes mug’s use in “incubation rituals.” These were ceremonies in which participants slept in sacred spaces to receive divine guidance through dreams. The rituals may have been performed in Bes Chambers, such as those at Saqqara near the Great Pyramids, where individuals sought confirmation of successful pregnancies—a perilous endeavor in the ancient world.

“This is the first time scientific evidence has directly confirmed the use of psychedelics in ancient Egyptian rituals,” said Tanasi. “We now have proof that Egyptian myths and practices were deeply rooted in reality, providing a window into their spiritual lives.”


A Blend of Science and Culture

The study was part of the Mediterranean Diet Archaeology project led by the USF Institute for the Advanced Study of Culture and the Environment. The team also collaborated with researchers from the University of Trieste and the University of Milan. By combining ancient science with modern technology, they created a 3D digital model of the Bes mug, enabling further study and public engagement.

“This finding validates written records and centuries-old myths about the use of hallucinogens in ancient Egyptian rituals,” Tanasi noted. “It underscores the sophistication of their practices and their advanced understanding of natural resources.”

Looking Ahead

The Bes mug is currently on display at the Tampa Museum of Art as part of the exhibition Prelude: An Introduction to the Permanent Collection. Researchers plan to analyze similar artifacts, such as those housed at the Allard Pierson Museum in Amsterdam, to determine whether this psychedelic concoction was a standard recipe for rituals honoring Bes.

This discovery confirms what many have long suspected: psychedelics were a significant part of ancient Egyptian rituals. With scientific evidence finally validating centuries-old myths, we now have tangible proof of how deeply psychotropic substances were intertwined with the spiritual and cultural practices of one of history’s most fascinating civilizations.

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